CAOS guideline · 2020

Hua and colleagues published a clinical guideline describing TTT for diabetic foot ulcers. This is professional guidance about a technique, not FDA device labeling or a patient adjustment schedule.

Multicenter cohort · 2022

Chen and colleagues followed selected patients with recalcitrant diabetic foot ulcers in a prospective multicenter cohort. The study reported healing and complications, but lacked a randomized comparison group; accompanying care and patient selection matter.

Ischemic-lesion case series · 2025

Rodrigues and colleagues reported a small prospective case series in patients with critical ischemic infrapatellar lesions. The population and small sample limit generalization. These findings do not establish MicroLift-specific or FTT outcomes.

Published TTT research

Systematic reviews published in 2023 and 2025 summarize reported TTT outcomes. Study populations, comparison groups, protocols and accompanying wound care differ. Read the original reports with your clinician.

Osteodistraction research · February 2026

Tarricone and colleagues reviewed 18 studies of tibial osteodistraction angiogenesis, a term used for the circulation-focused application of TTT. The review reported encouraging wound-healing and circulation findings. Differences between studies and limitations in the evidence mean that randomized trials are still needed. These findings are about the technique and do not establish MicroLift-specific or FTT outcomes.

TTT alongside vascular treatment · July 2026

Lavery and colleagues reviewed five studies comparing TTT combined with revascularization with either approach alone. The analysis found an association with better wound healing in the combined-treatment groups. The small evidence base requires further trials; it does not show that TTT should replace appropriate vascular treatment or predict an individual result.

International case experience · 2024

A three-case report described TTT in difficult lower-limb wounds with chronic limb-threatening ischemia. Such reports help explain clinical experience, but a small uncontrolled series cannot establish comparative effectiveness or typical outcomes.

Important limitations

Selection bias, observational designs, different follow-up periods and differences in standard care can affect interpretation. A high reported healing rate cannot be used as a personal prognosis.

Technique evidence and device evidence

Evidence about TTT is not automatically MicroLift-specific evidence. Device performance, clinical outcomes and regulatory labeling answer different questions.

FTT evidence

Fibular transverse transport has appeared in early publications, including a 2020 case report and a small 2022 comparative study. These used different protocols and do not directly establish outcomes for Response Ortho®’s approximately 5 cm segment method. The broader technique literature and evidence specific to this method must be assessed separately.

A balanced discussion

Discuss healing, complications, recurrence, mobility, treatment burden and the possibility that treatment may not achieve the intended result.

Sources & further reading

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What does the evidence tell us?